Duchenne Muscular Dystrophy: Management of Difficult Airway and Concurrent Bronchospasm
نویسندگان
چکیده
Using succinylcholine and inhalation agents for patients with Duchenne muscular dystrophy is extremely risky. Those risks include heart failure, cardiac dysrhythmias, rhabdomyolysis and malignant hyperthermia. Even in emergent situations, such as intraoperative bronchospasm, succinylcholine and inhalational agents are often considered contraindicated. Nevertheless, if intraoperative bronchospasm does occur in a patient with Duchenne muscular dystrophy, the benefits of using inhalational agents to treat bronchospasm may outweigh the risks in certain situations.
منابع مشابه
P164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
متن کاملDetection of the Duplication in Exons 56-63 of Duchenne Muscular Dystrophy Patients with MLPA
Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...
متن کاملPerioperative management of a patient with Becker’s muscular dystrophy
Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD) are progressive neuromuscular disorders resulting from mutations in the dystrophin gene. BMD presents similarly to DMD, but generally has a milder clinical course. Clinical features include progressive weakness beginning in the proximal leg and pelvic musculature with eventual involvement of the upper limb, shoulder, and neck...
متن کاملAirway clearance in Duchenne muscular dystrophy.
This is a summary of the presentation on airway clearance in neuromuscular disorders presented as part of the program on airway clearance in Duchenne muscular dystrophy at the 30th annual Carrell-Krusen Neuromuscular Symposium on February 20, 2008.
متن کاملIntensive Management of Chronic Bronchorrhea in a Tracheostomized Duchenne Patient with Bronchiectasis
Duchenne muscular dystrophy (DMD) is a severe neuromuscular (NM) disease, considered as the most common and rapidly evolutive muscular dystrophy. The incidence of this X-linked hereditary disease is approximately 1/3000 [1] to 3500 [2] male births. DMD is caused by mutation of the dystrophin gene which leads to the absence of dystrophin in muscle tissue [1] Missing dystrophin precludes normal m...
متن کامل